When you cross a bad case of thrush and a one night stand with Billy Ray Cyrus
Patient : I have an Itchy Twitchy Twat
Doctor : I told you to stop seeing Billy when you have thrush
by KiNeTiK August 18, 2004
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A syndrome affecting 90% of all single males on the internet every Sunday morning. The condition is more acute in those not having pulled on the Saturday night before... Usually sufferers can be found lurking in chat rooms or using IM desperately seeking a female to cyber with.
haha just because you got twitchy wink syndrome doesn't mean Im gonna get my tits out on cam for you!
by Granny Weatherwax September 25, 2005
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Someone who's uncertain, or has a tendency to contradict themselves.
Jake: "Man, my girl can't decide whether she want's to stay or leave."

Paul: "Oh damn she's a twitchy bitch."
by Mistha Cack April 25, 2019
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Involuntary muscle twitching while high/stoned
Hey Greg, I got the twitchies! My legs are cramping up!
by December 18, 2020
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After slam-dunking a fucking hair tie like Kobe Bryant in a hot bitchez tittie Cleavage... Your cock can't stop won't stop twitching like a pos Chihuahua from Guatemala's most dangerous neighborhood.
by RockAndCock Rock 1st! December 12, 2019
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A phrase used by an elderly grandfather to describe his hyperactive grandson's frequent movements.
Settle down boy, you're gettin all itchy gotchy with the twitchy twachy!
by JefferiahtheMessiah April 16, 2022
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