To become suddenly affected by an unfortunate event (namely in regards to unfortunate encounters with girlfriends) and to take on a depressed demeanor in response.

Also: Quite literally, the victim's penis twists up and resembles a cork screw. Only alcohol and the lubricating function of the vagina can undo this twisty-dick-ness.
Your buddy just breaks up with his girlfriend:

You: "Awww.. Who has the twisty-dick?"

Your buddy: "... I have the twisty dick..." :(

You: "It's okay, buddy... We'll find a bottle of Jack and a couple of hookers to untwist your twisty-dick..."

Your buddy: "Thanks, buudddyyy...." :D
by JDSmith February 17, 2010
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The most dangerous skateboard trick ever conceived. First done by Bob Burnquist at the 2011 California Butt Jam. The trick proved so difficult that the pure centripetal force involved fractured six ribs and dispelled enough heated kinetic energy to scorch local fields and vegetation. Under no circumstance should this trick ever be attempted. If recreated, God herself will shed a tear.
“Hey Josh you ever end up getting that date with Mindy for Friday night?”

“A date with Mindy ANY night is about as possible as a Dick Twisty to 1080 Biggie Smalls Ball Grab, Drake!”
by IgnorantMedia January 10, 2022
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