Top Definition
The same thing as busting someone's balls, except females don't have balls...so, they get their tubes twisted instead. Giving a girl a hard time about something, beating them down with negative comments and insults.
Yeah, I know I shouldn't have dated that crackhead cousin of yours. So you can stop twisting my tubes already, okay?

My boss has been twisting my tubes all week about missing that deadline.
by G-Nice January 21, 2011

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