Top Definition
1) A persistent infection affecting the speech and decision-making areas of the brain. Patient becomes infected through exposure to contaminated materials such as the Twilight Series books, movies, or swag. Results in Twilight logorrhea (babbling) and faintness at the sight of sparkles or fangs. Condition primarily affects females in the 13-60 age range, and is currently incurable.

2) An addiction to Twilight, that rots the brain from the inside out.
Oh man, will you look at her? She was so hot until I found out about her Twilyphilis.
by SocioTom June 03, 2010

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