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1. A nickname that was made up by combining "Tweety Bird" and "Tweak". The spelling was changed and the "Bird" part dropped

2.A nickname that implies us of the stimulant drug crystal meth.
1. "People call her 'Tweekee'... I think she Tweaks meth."

2."Your always tweakin' out, girl! Ima call you Tweekee"
by Tweekee October 03, 2008