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1.
To freak out or spaz out over something. Usually happens when the person twakin is intoxicated
Quit twakin we'll find your phone
by Scrapper Joe January 30, 2011
 
2.
waking up in the morning tweekin
OH yea yea yea! Today is saturday. Carlos, its just saturday, stop twakin and go back to bed again.
by pungent November 29, 2006
 
3.
A higher version of tweakin or a higher version of trippin
You paid $20 for a nickle bag,aw you twakin
by CHEIF BRADLEY December 29, 2010