Thizhead Share definition Flag A person that abuses Ecstacy. Thiz deriving from the Mac Dre slang for Ecstacy. see also, E-tard. "Eminem is a thizhead. He'll never last, the only class he'll ever pass is Phys Ed." - Eminem, "As the world turns" Thizhead by Jimmycthatsme October 23, 2006 0 0 Get merch Get the Thizhead mug. Buy Now — $32.95 See more merch