This is a more inside way of saying you have to drop a deuce (take a crap), it works really well in an office setting so that you may let your close, personal co-workers know where you are going without letting everyone else know. This is derived from John Wayne's nickname being "The Duke", and can be shortened by simply saying "I have to make a phone call", or added to by saying "man John Wayne has been calling me all day."
"I'll be right back I have to make a phone call to John Wayne."

"I'll call you right back John Wayne is calling me on my other line."
by the crab show July 8, 2009
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Verb: A term used to describe a difficult bowel movement. A play on word based on his nickname, "The Duke."
We might be late to the movie. I need to drop off John Wayne.
by J. Lightning August 28, 2010
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ay man i gotta go my girl want me to come over and i aint got nothin. so ima go buy me a box of dem thangs that killed john wayne
by shay shay baby April 12, 2008
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(n. - pejorative)

A predatory, middle -aged cab driver often found trolling Chicago's north side neighborhood bars around 4 AM. Explicitly fond of adopting the role of "daddy" for one or multiple "sons." May or may not express a desire to engage in light bondage, optionally involving toys. Individual possesses a questionable and unsettling familiarity with a victim's close friends.

See also: "predatory closet job."
Dude, if you're cabbing home after the bars close, it's safer in groups... you might end up with John Wayne Maybe.
by IvyLeague86 November 14, 2014
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A nice and loving guy. The best man a woman could ever find. The guy who means the world to you.
by Jld72014 February 4, 2017
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