Top Definition
Pursuing an activity to the exclusion of all else. The activity could be: driving non-stop, studying all night or longer, going on a drug jag or just about anything else.
I need to get home. No rest stops for me. I'll be straight running to Boston.

I didn't study my Sociology all semester. I'll be straight running for two days before the final.

That guy should get help. He's been straight running on junk for three days.
by 73Guy June 20, 2012

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