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2.
Derivative of son of a bitch. Usually employed to denote extreme displeasure in a person, place, or thing.

In close kinship with a whore.
"Fuck you, you fucking son of a fuck!"
by Davey November 28, 2004
 
1.
Any one man whose parents have had sex.
You dumb son of a fuck!

Anyone but Jesus and Adam.
by Scoepio July 10, 2008
 
3.
It's originated by Pewdiepie in one of his videos. Instead of "Son of a bitch"
OHHHHHHHH SON OF A FUCK!
by Boobie lover October 23, 2013
 
4.
a phrase that can only be said by mickey medina.
"Son of a fuck!"
Oh, whats up mickey?
by Nobody To Exsist May 31, 2010