It's a somewhat degrading way to call someone a "sister" because at the same time you're calling them a man.
Christopher + Sister = Sistopher.
Just like Joseph + Brother = Broseph.
Guy: What's up Sistopher?
Girl: -________- Nothing BROSEPH.
Guy: Lol wow. Really?
Girl: Yesh :b
by TheOppositeOfYou November 27, 2011

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