Used to be sassy, sarcastic, SIS.
Sis is just such a cute word!!!
Sis-

Sis- NO
Sis that's so cute!
by t_xo88 September 27, 2020
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avery: he called me sis. i've literally lost sleep over this. what does it mean :(
noah: you just got sibling-zoned
by nopo2 November 6, 2022
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Word used by bitchy Twitter Stans in a usually rude context, who think that they are top shit. These Stans are usually female, and tend to overuse words such as Tea and Y’all.
Twitter Stan: Sis..
Me: You know, I’m just about done with your shit, “JunkookFangirl97”.
by MeganTheCreator April 2, 2019
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Sis is the noun for describing a queen who is in shock.
Ciara: Omg i met Sammy last night

Ben: OMG sis
by Ciaranadben October 14, 2021
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girl mentally ill who doesn't know what's going on

falls in love at people who are terrible don't respect her and hate her
everyone who was friends with her hates her and wishes her death
she loves herself

loves to talk about her feelings
her astro birth chart say she is awful person
Sis you can't fall in love with him, he's an imitation of a man, he's not even a half man
by Borntodiesis July 8, 2021
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girl mentally ill who doesn't know what's going on

falls in love at people who are terrible don't respect her and hate her
everyone who was friends with her hates her and wishes her death
she loves herself

loves to talk about her feelings
her astro birth chart say she is awful person
Sis you can't fall in love with him, he's an imitation of a man, he's not even a half man
by Borntodiesis July 8, 2021
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something you call a girl if you have a close relationship with them
sis he is cute

sis watch out
by madmeeps May 2, 2019
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