look up any word, like dirty sanchez:
 
1.
To look shaggy or disheveled.
John is looking rather scrofulous today.
by Travis April 18, 2005
 
2.
To not look your best. To look ugly, hit, like a bum, etc.
Eww, you look scrofulous today.
by thatonestraightupgangsta March 15, 2011