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1.
Used first by the lovely Nimz to describe awesomeness related to video game personality Stuttering Craig's website - screwattack.

Anything that is awesome, fun, fresh, and/or original.
I'm having a screwsome day, now that I'm finally finished with work.
by Dyslexic Heart August 17, 2008
 
2.
A couple (MF FF or MF) who regularly hook up with other people for three way sex.
He was lucky enough to find a screwsome that wanted to hook up every weekend.
by texdeepdrill February 01, 2007