Top Definition
A TOTALLY AWESOME LATIN ROCK BAND, LED BY THE GUITARIST OF THE SAME NAME.
There's only one Santana, his first name is Carlos - and he plays the meanest guitar in the world !!
by .l April 28, 2014

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Photos & Videos
a kickass guitarist that combines blues rock and latin music in one
did Santana ever play with Jimi Hendrix?
i wish it, that would've made someone jizz theirself if they ever heard that song
by D money 9295 August 19, 2010

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Santana as in "Saint-Ana". Sanatana means a saint very holy and clean. Originated in spain;
Carlos Santana, guitar player; Juelz Santana aka. DipsEt, rapper.
by Jezebel Santana December 07, 2007

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The most perfect girlfriend you could ever find. Great smile. 10/10. Never let her go because you're definitely going to regret it later in life.
1st girl: Damn is that a Santana with my ex?
2nd girl: Shit, you just lost the ex game.
1st girl: *Starts crying*
by Bluebro11 July 28, 2016

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A ride-or-die chic who always tells it like it is. She's loyal til the end to those who are loyal to her. She has long dark hair and dark piercing eyes that has the ability to stare right into your soul. She's one of the hottest bitches on the block and she is what every man dreams of. She's got the whole package once you have her you don't want to ever let her go. Santana is a freak when the lights go out once you have had her you'll never forget her and you won't never find another like her even if you search far and wide she's one of a kind.
That's Santana and she is a down ass bitch she been A1 since day 1.

I can always count on Santana when I need her.

Damn Santana got that good good.
by Mind-Wonderer October 17, 2016

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A nice, beautiful, hot, caring, funny, and wifey material girl. A honest friend ,never lies , and sometimes annoying. Has long curly hair, nice lips, and big thighs. Also is single.
Boy 1) Who is that hot girl with the curly hair over there .

Boy 2) oh you don't know her ? Thats Santana.
Boy 1) is she single???
Boy 2) yes she is.... you should go ask her out
Boy 1) I will
by Felica145 November 17, 2016

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The Urban Dictionary T-Shirt

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The best friend a girl could have, funny with a great smile. White girl that loves black dick, A LOT. A lady in the streets but a freak in the streets... or backseat of a car.
"who is that girl with that black guy?"
"not sure, she's hot though so she must be a Santana."
by 666birdhomes March 28, 2015

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The Urban Dictionary Mug

Your favorite word on a white mug.

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

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