SUPOLOPOLOPISIS Share definition Flag 1. A disease which infects the brain directly, resulting in a deadly combination of insanity and brain cancer. Person 1: DUDE I HAVE SUPOLOPOLOPISIS Person 2: LOL pwned SUPOLOPOLOPISIS by super-mega irishman December 8, 2006 0 0 Get merch Get the SUPOLOPOLOPISIS mug. Buy Now — $32.95 See more merch