The pattern of symptoms revolving around a complete and utter failure with all members of the opposite sex.

These symptoms usually include, but are not limited to:

Never getting sex,

All plans with the opposite sex fall through 99% of the time at the absolute last minute to make you feel even shittier,

Any relationship you may think you're in only lasting a maximum of two weeks,

Your partner leaving you after only a short amount of time for another person,

The new person you just went on a date with having had a guy over the night before your date,
The only people that want you live over 12 hours away,

Going out of your way to see someone who is a special person to you only to be broken up with after going through all the trouble, and
Having the previous thing happen multiple times with multiple people.

Basically having a case of Murphy's Law of the opposite sex.
How'd it go with ole girl last night? - guy2

Her sister went into labor last night so she canceled before she even met me at the theater - Ryan

Ryan Syndrome? - guy2

Ryan Syndrome - Ryan
by the woogier June 14, 2011
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Ryan Gosling Syndrome is a disease that 14 year old boys contract after watching the hit movies Barbie, Drive, and Blade Runner 2049. It causes them to believe that they are “literally Ryan gosling” and whenever they see Ryan Gosling they have to point out that it’s them or they will spontaneously combust.
Boy 1: Did you hear Ben and Raf contracted Ryan Gosling Syndrome?

Boy 2: Yeah, I believe they saw the movie Barbie and now they both think they are Ryan Gosling.
by BanjoPaintCan August 13, 2023
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A man so attractive, everyone is sexualy attracted to him, regardless of previous sexuality.
"That dude was so hot. Dude gave me Ryan Reynolds syndrome.
by DragonDino21 May 20, 2023
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