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That Really Rustled My Jimmies” is an expression that is used to convey feelings of discontent or discomfort in response to someone else’s post in imageboards and discussion forums, most notably on 4chan. To rustle one's jimmies means to make someone discontent or to bother someone.
Man 1: "This guy is your boyfriend? He's worthless!"

Man 2: "That really does Rustle My Jimmies man..."
by Carlos-a-16 June 08, 2012
Repositioning sexual organs. For males, repositioning of the penis and testicles. For females, repositioning of the breasts.
In awkward situations I like to rustle my jimmies
by Skewesy October 20, 2013