A retard slut whore usually stands for a really annoying person, like a dump-ass wanker, slutty bitches in a mall talking shit, or maybe your sister acting retarded all day long, bitching around just because her gay boyfriend told her that she's a bitch.
Jim: You want Daddy to give you a spanking in front of his retard slut whore?
Betty: I'M NOT RETARDED!
(accepting being a slut whore).
Girl: damn it, I just broke my computer!
Dude: you retard slut whore!!