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1.
RFU
Royally Fucked Up, as immortalized by the stupid-but-enjoyable comic series (also titled RFU). It can also pretty much be exchanged with any other term.

Also, some crap involving rugby. But mostly the comic thing.
"This shit is RFU. Let's go RFU all over the RFUniverse. Also, RFU."
by Jack Barton January 23, 2006
 
2.
RFU
Remain Fucked Up
Spike: Disco, do you want to RFU for about a week?
Disco: Sure, let's make it two weeks.
by Johnboy Thomas June 07, 2009