Top Definition
A massive explosion of vomit, covering several rooms, coming from a wasted guy/girl after a night of heavily drinking.
Friend: Wow, it smells! What happened?

Dude: I totally made a Puke Nuke last night.

Friend: Wicked!
by Masterpuker November 03, 2010

Free Daily Email

Type your email address below to get our free Urban Word of the Day every morning!

Emails are sent from daily@urbandictionary.com. We'll never spam you.

×