"Profo" can be used when talking about a whorish girl or it can even be used to describe a guy who gets around as well.
Becca: "Hey Taylor, did you hear that Sue hooked up with 4 boys last night at that frat party?"
Taylor: "Four?! Damn, what a profo."
Becca: "I heard back in high school Eric had a new girl friend every other week."
Jeff: "Yeah, Eric used to be a huge profo."