Top Definition
A take off on Jennifer Lopez's "J-Lo". Prez-BO is the hip "street" name given to President Barrack Obama by conservatives.
Guy #1: "Did you hear about that crazy shit Obama is trying to pull with the cap and trade thing?"

Guy #2: "Geez, I guess that's Prez-BO's idea of change you can believe in."

Guy #3: "No shit, change is all I got left in my pocket."
by The Original Big Daddy G July 10, 2009
5 Words related to Prezbo
President Barack Obama.
This Prezbo guy... he looks a lot like Curious George.
by thePrezzz February 06, 2009

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