Top Definition
A disease which causes many teen males to stay home from school in order to rank up on call of duty. The only symptoms of prestige disease are a long period of time spent playing the game, and rapid ranking up by a player on Xbox.
"Mike, do you know why Paul never showed up today?"
"I heard he stayed home because he has prestige disease, he has played two days of Call of Duty in the past week."
by TheGreatJamal April 08, 2010

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