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3.
Pronounced pre-mee. Synonymous with pre-med, premed, premedical. Used by current medical students, residents, and attending doctors to describe premedical students. Puns: pre-me as in before me, a premature version of me as in premature babies often referred to as preme, as in premature babies born before gestational age.
Look at that gunner pre-me, he's never gonna get into medical school.
by yukysaky May 03, 2009
 
1.
Preme is fashion/street slang for the NYC based clothing brand Supreme. Brand that targets the Skateboarding, Hip hop, and Punk rock cultures.
Male 1: Yo bruh bruh, what day is it?
Male 2: It's Thursday, main man.
Male 1: Fvck mayne ... missed the preme drop
by GavinRC May 15, 2013
 
2.
adj.
preme is a combination of supreme and premium, used to describe the enjoyment of something, usually concerned with food or sex.
"that sandwich was preme."
"she gave me a preme blowjob."
by skeet keet March 09, 2006