Top definition
The nagging and persistent melancholy that follows a night and/or day of binge-drinking, especially if you have done something regrettable during that time. This is usually coupled with a hangover.
"I was laying in bed all day with a bad case of 'post-booze blues', after unsuccessfully trying to hook up with my boss last night at the Christmas party"
by Ned Shaver December 11, 2009
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