To do something that you know annoys someone frequently, risking a violent outburst the more the action is done. It refers to an online game, where a rabbit is poked, until it eventually bites the mouse. Often shouted out to someone as a warning that what they're doing can get them hurt.
Guy 1 pokes Girl 1 who does not like being poked. Guy 1 pokes Girl 1 again and again
Guy 2 to Guy 1 - "Don't poke the rabbit man. She'll kill you."
Guy 2 to Guy 1 - "Don't poke the rabbit man. She'll kill you."
by Shambles299 April 12, 2011