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Pixburgh is the equivalent of Pittsburgh. When Pittsburgh natives pronounce their city's name the combination of accent and the tendency to speak quickly create an "ix" sound where there should be an "itts".

It is often considered a word of Pittsburghese.
I'm from Pixburgh.
by Narcifosho March 26, 2011
pittsburgh's right name, as pronounced by a native.
tanite ahm gaahn dahntan pixburgh to watch the stillers win
by ssword July 23, 2011