Top Definition
n. A mixture of piss and puke, most commonly brought on by drinking and such.

v. Simultaneous pissing and puking.
"You should try to avoid that puddle of pisspuke in the kitchen."

"Bro, did you see that guy last night? He got wasted and pisspuked all over himself. It was mad gross."
by Shawn Greggs April 23, 2008
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