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1.
Piperazine is a drug that belongs to the family of medicines called anthelmintics. These medicines are used in the treatment of worm infections (roundworms, pinworms). In the past few years, illegal drug manufactures have used piperazine in the production of ecstasy tablets as a cheap substitution. These manufacturers are mostly concentrated in Canada, where the drug is legal and over-the-counter. Piperazine is an ideal choice for making fake ecstasy because of the similarity in taste, and at certain doses, a user may experience favorable side effects and feel “high.”
"I got ripped off and bought some bunk piperazine pills."

"That ain't e. Homie, you got piped."

"Green ninja turles, yellow bart simpsons..."
by alf321 March 25, 2009
 
2.
A cheap drug that is put in E to make up for MDMA and speed. Piperazine is an over-the-counter drug that is meant to help bloating, it resembles the taste of MDA (similar to MDMA) and this is why it's put in as a cheap alternative.
they put piperazine in my E!
by filter23232323 October 12, 2008