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1.
Fucking a Girl so much that you ruin her Pussy/Tearn' That Pussy Up.
Yo, I Fucking Picasso'd that bitch last night. She won't forget this mofucka right here!
by A-Wad March 21, 2007
 
2.
The look on someone's face after returning from a long night of partying and bar crawling. This night usually consists of an immense amount of cheap alcohol (and most likely, drugs as well).
Dude, did you just get back from the bar? You look picasso'd!
by Micah Jesse February 13, 2006