Top Definition
The state of mind a person is left in once they have taken too much Acid, Shrooms, Thizz, or Extacy. Once there are too many holes in your brain from taking these drugs, you are left in a blank state of mind, or left in a state of mind where you are always thizzed out.
"Dude, I haven't seen Frank in 3 years! This is how he acts now?"
"Yeah, sorry man. He took too many shrooms and popped too many pills, now he is Permathizzed"
by Thizz Monkey January 16, 2010
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