1. Someone who is always in a bitchy mood and/or PMSing.
Sam: "My mom is always pissin' me off and bitchin' me out."

Gage: "Dude, she's a perma-bitch."
by GageT90 June 1, 2009
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Getting way too high on any "hard" drug, or psychodelic, (everything from meth, lsd, pcp,shrooms, malli, cocaine) or for to staying high for too long, and never coming down.
Billy took 15 hits of acid and got perma-spun, he hears voices and shit now.
by johnyappleseed May 14, 2013
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When a man has permanently hard nipples at any temperature. They are very sexy, despite their ability to cut glass.
Are you excited to see me?

Yes, but it's my perma perk
Can you cut glass with those nipples?
Hell Yea, I'm Chad and it's perma perk, i can cut anything with these nipples
by Bulyeabiotch May 22, 2017
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A condition existing in women, consisting of a state of constant irritation and an excessive amount of anger. usually directed at males that are in close relationship with the victim.

PMS symptoms that don't seem to go away.
your girlfriend is always so mean to you. she must have perma-period.
by fliggs December 5, 2007
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Ultimate in cool, cooler than permafrost.
That gig was beyond sick; totally perma-pressed.
by fabetismo November 17, 2016
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To constantly act as if you are in the setting of a rave or being high on ecstasy at a rave, even when you are sober and not at a rave. Also, being very attracted to bright pretty things.
Kari, stop dancing like that! You are so fucking perma raved, we are at the mall!
by joeldg June 9, 2007
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When you have consumed enough alcohol and or illegal substances to kill off a few brain cells used for speaking. Resulting in slurring most of your words.
whats up mannnn i havn seeeennnnn youuuuu in foreverrrr.

what are you saying dude?

I have a fuckingggg perma-slurrrrrr.
by yourpseudonym. June 25, 2010
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