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1.
In Mexico: its one of several slang terms used for a girl's pussy a.k.a. vagina.

En Mexico es una palabra conocida como la chocha de una mujer.. alias Vagina.
1. She said her pepa gets wet when she gets aroused.

2. Ella dice que se le moja la pepa cuando se excita.
by chocu November 28, 2006
 
2.
A slang term for a grandfather. Used in many southern states, including Texas, Arkansas, Georgia, and Louisiana.
"Hey Pepa! Where you goin'?"

"I'm headin' back into the house to get your Mema."
by texarkanaborn November 02, 2012
 
3.
In Colombia: A person whose intelligence is above the average.
Someone characterized for being smarter than others.
Carlos es el mas pepa de la clase.
by Mario F Monsalve December 12, 2005
 
4.
A nickname for someone's grandfather.
Me: "Aunt Maria, have you seen Pepa?"

Aunt Maria: "Yeah, he went out with Mema."
by CrystellaMarie October 23, 2008