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1.
The region of Pennsylvania not found within either the Philadelphia or Pittsburgh city limits.
I'm headed up the Northeast Extension into Pennsyltucky.

See (Pakys)
by anonymous February 21, 2004
 
2.
Rural parts of Pennsylvania with large concentrations of country folk, noted for interest in Hunting, Country Music, NASCAR, trailer life, Wal-Mart and working at the plant. Often spotted wearing camouflage with full grown beards or unkept caveman appearance driving pickup trucks with gun racks. Note: PA has the largest Rural population of any state, not everyone who lives or is from these regions is a red neck, hick or country bumpkin and most who don't dislike the reference "Pennsyltuckey" and find it insulting.
The Film "Deliverance" well not that extreme all the time in Pennsyltucky
by Brian Lauskies September 26, 2006
 
3.
The large section of the middle of Pennsylvania where more cars are seen on lawns than the roads. Cousin sex is acceptable, and New Jersey license plates are generally despised.

**Note: The greater Harrisburg-York-Carlise region does not follow the general definition for Pennsyltucky. People there are civilized and own homes instead of trailers, yet don't carry the asshole persona you might find in Philadelphia. However, even here Jersey is despised. New Jersey sucks.
I drove 50 miles outside of Harrisburg, and some guy in Pennsyltucky made me squeal like a pig.
by brspenn May 15, 2009
 
4.
refers to a stretch of land (mostly in the Apalachian Mountains) ranging from Kentucky through West Virginia and into Pennsylvania where double wides, stock cars, and pick up trucks dominate....
by Anonymous August 16, 2003
 
5.
Often referred to or directed towards the state of Pennsylvania however the second syllable "tucky" or "tuckey" can also be applied to any state name, akin to the stereotype that Kentucky is full of red necks and backwoods Bubbas though anyone with common sense and is well traveled know they exist in all 50 states in some shape or form.
Travel the 50 states and look around and you will see Pennsyltucky in everystate.
by John Smither October 10, 2006
 
6.
refers to a location deep in the middle of nowhere.
My grandparents live way out in the middle of pennsyltucky.
by steiz October 02, 2011
 
7.
The region of the United States stretching from northern Pennsylvania, south through the center of Pennsylvania, west into West Virginia and finally into Kentucky. Pennsyltucky is a continuous region bound together by similar demographics and geography. At about two-hundred miles wide and nearly a thousand miles long, Pennsyltucky composes a large area of the
eastern United States. Generally, the region does not include urban areas, with Philadelphia and Pittsburgh most commonly cited as excluded. Everyone's welcome though!
Pennsyltuckian: "Let's drive across Pennsyltucky, there's a bluegrass festival in Louisville this weekend!"
Non-pennsyltuckian: "What?" "Yuck!" or "I don't know, is it safe?" or "Is there any good shopping on the way?"
Pennsyltuckian: "..."
by A pennsyltuckian February 24, 2011