a real pain after a person experienced anal intercourse
Ouch, I need to go to the doctor because I have pain in my ass.
by Andav October 22, 2008
When a person is annoying me specifically
He keeps interrupting me when I am busy, so he is a pain in my ass.
by Jess Z October 22, 2008
Someone whose sole existence is to piss you off and bother you.
John, you are being a really big pain in my ass today.
by Happy wife happy life July 14, 2015