Top Definition
PKU
PKU or Phenylketonuria is a rare genetic disorder in which the enzyme phenylalanine hydroxylase that converts phenylalanine (an amino acid in protein) into tyrosine does not work properly or at all. In this case the phenylalanine builds up in the blood stream and becomes toxic to the central nervous system. This can cause nerological complications like a lack of concentration, mood disorders, loss in IQ, memory loss, and sometimes severe mental retardation. There is no cure for PKU but the treatment includes low-protein diets and medical formula that gives you your lacking nutrients. PKU has been tested for at birth in the USA sine 1965.
I have a rare, inherited metabolic disorder called PKU.
by pkugirl July 09, 2011

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PKU
Means please kill yourslef.
#1

Mikey McFag: OMG GUYZ comment my new pics i took of myself in my bathroom with my iphone!

Carolyn: PKU

#2

Douchey Bus Driver: I DON'T BELIEVE IN SECOND CHANCES. SIT DOWN IN YOUR ASSIGNED SEATS.

Carolyn: PKU PKU PKU
by ynamreGJa September 15, 2010

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