Top Definition
Roughest area in the Midwest, by the Ohio river in Cincinnati, has several shootings daily, home of the rapper Tocka.
Man lets drive the other way, we re getting too close to Over the Rhine.
by elBrendo September 10, 2006
Was just announced the most dangerous place in american. It's a area in downtown Cinciannti aka nasti nati. Over the rhine is known for high crime rate. You won't even hear about half the criminal acts that go on in over the rhine because cops and/or people who are not from cincinnati are too afraid to go there. Nasti nati doesn't have all the rappers but we are so dangerous.
Hey brah, did you hear about the riots all over downtown. They started in over the rhine.
by kirkisKING June 30, 2009
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