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1.
A special over the counter anti oral pain relief cream that nullifies the pain in a persons mouth weather they got jawed,toothache,loose tooth,lock jaw, it's very thick and looks like cum but it really works you won't even remember your in pain.
Drake got got KO'D last night in a bar and lost his front teeth,he was in so much pain he had to use Orajel.
by Virgil Hampton February 14, 2009
 
2.
A medicine used over the counter to numb the mouth, so as to take away pain.
The other use, which is better, is to put it on ones genitals to make sex last a very long time. Unfortunately sensitivity is decreased so it is a double edged sword.
I put orajel on my penis and lasted 3 hours.
by Hawn Gnarley August 12, 2014