If you do something once too often it means that you have repeated an action which is bad, stupid or dangerous with an unpleasant end result. So you end up looking a complete wanker, in A & E with serious injuries or someone is totally pissed off with you to an extent which is going to be detrimental to your health and wellbeing.
He’s pissed them off once too often, they’re going to put the fucker on crutches.
by AKACroatalin December 14, 2016
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Aside from being the most cliched pick-up line, this phrased is used can be used in other social situations.

1. What you say when you are in a group conversation and everyone randomly stops talking.

2. What you say when you first arrive somewhere after your friends have been there longer.
Ryan: HAHAHAHAHA
Aaren: hahahahaha..
Alan: hahaha..........
....

<silence>

Scott: So.. you come here often?
by Ryan=pro June 16, 2005
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The Hickish or White Trash way of saying periodically.
We went to visit them every so often.
by Wolga June 19, 2006
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A word used to describe bafflement
Henry: Jeffry, that woman you are marrying has a penis

Jeffry: I'm confused!!!
by hahaha July 23, 2003
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This is Trumpspeak for "usually the most," since Trump only knows two degrees, most and least.
I am often the least racist person that anybody is going to meet.
by Catty McGee January 26, 2018
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A phrase you say to a girl when your about to close to make sure you get the job done and prove you are smooth as ice.
Man: You Come here Often?
Girl: *Amazed and Stunned by the amount of smoothness and swagger exemplified*
by NickySalami November 29, 2021
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When someone is sure of their opinion, but unopen to facts, truth, and light entering their mind, heart, and soul.
Patty complained that I like to check facts, but she prefers to trust her instincts. She is often-wrong: never-in-doubt.
by JaneGordon.com March 9, 2023
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