To lose one's mind, go crazy, insane, batshit psycho. Usually caused by lack of sleep, hyperactivity, sugar or plain ol' weirdness.
Erma has gone completely off the rack. We need to put her in a straightjacket and lock her in a glass box at a museum for the psychologically insane so that everyone can witness the true heights weirdness can attain.
by Artichokes October 23, 2013
by NinjaSticks December 11, 2008