To be under the influence of meth or a similar substance.
Damn,man!I saw that fool Kyle the other day,homie....That fool was on a hot one!
by LbcSlim1 December 20, 2007
Can you define these popular missing words?
In the middle of a hot crime spree.
That westside crew is on a hot one!
by Caroline Byrne August 23, 2005