Top Definition
OFIFU is the acronym of the phrase "Oh Fuck I Fucked Up".
It can be used in replacement for your friends name when they do something stupid aka fuck up!

This also can be molded into various forms:

Ofifian: a race of people who fuck up
Ofifed or Ofifud: both the verb form of Ofifu
"fucking ofifu, your such a dumb bitch!"
"I think victor is a ofifian he is always fucking up"
"Dick my condom rip when i was in this bitch i ofifed.
by Arzebby June 14, 2011

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