Top Definition
A dangerous mental condition that quarterbacks in the NFL suffer from, especially those such as Tony Romo when they know they are about to get owned by dangerous players like Brian Orakpo of the Washington Redskins.
Omg, did you see Tony Romo and his O-sack-pophobia that led to the interception by DeAngelo Hall? Then all of a sudden, Santana Moss caught the ball from Jason Campbell and the Redskins won the game.
by Redskins_Own November 19, 2009
5 Words related to O-sack-pophobia

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