Top Definition
Pronounced: (new-cee-ano)

Also known as: Nuisance

1. A human that constantly does ANY of the following: talks (usually loudly), yips, yaps, clings to you, follows you around, incessantly calls/texts, annoys the living shit out of you on a day to day basis.

2. A human that gets involved with other human's personal matters.

3. A human who continues to "nuse" you even when you have repeatedly referred to them as "Nusiano" in place of their first name.
If that Nusiano touches me one more time, I am going to knock her the fuck out.
by Stephanieo July 05, 2011

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