Top Definition
The act and verbal expression of a person showing their fear by hastily leaving a room, household or building. Can also be used in past and present tense.
Sarah: So I had to kill a spider in the living room because my brother NopeNopeNope'd out of the room.
Jason: Wow, what a wuss!

Daryll: You better not NopeNopeNope during Insidious 2 like you did the first one.
by herooftime89 September 26, 2013
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