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NejiSaku is a shorter way of saying "Neji x Sakura" It is a pairing that consists of Sakura Haruno and Neji Hyuga from the anime/manga Naruto.Although (sp?) compared to other pairings such as NejiTen,or SasuSaku NejiSaku may seem "small-ish" it is actually quite popular among fans in fanart and doujinshi.
In my opinion,NejiSaku is pointless because Neji and Sakura barely even know eachother that well.
by Fandom's Cheese October 22, 2009