The small flakes of dried, dead skin, left behind by (usually chaffed) testicles in underwear.

"Nadruff" can also be a mixure of debris such as chad particles, semen, urine and other bodily /non bodily fluids that have dried out and crusted off.
*GIRL* licks guys testicles/nut sacks
*GIRL* Omg i got something in my mouth from your balls and its kind of chewy.
*GUY* Oh shit i must have nadruff!.

"BRO my balls are kinda itchy" , ...
"Haha, last time my nuts were itchy i went to have a wank an seen that there was "Nadruff" in my boxers!"
by Tease Nismo September 26, 2020
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