look up any word, like fluffer:
 
1.
Short for Now That's Fucked Up
Dialog on IM

A: I play with my feces.
B: Damn man! NTFU! :(
by heroshima April 27, 2007
 
2.
nicen-the-fuck-up, that people should be nicer to each other and speak to each other more civilly and in a way that Miss Manners would like
Twitter users should nicen-the-fuck-up #NTFU
by ggtoo September 22, 2010