To do amazingly or surprisingly well, deriving from Dungeons & Dragons, where a roll of 20 on a twenty-sided die nets an automatic success, usually done with and recieved with gusto.
"These dudes were in my face and I punched this guy in the face. Nat 20 and he was down."
by Akhenaten April 8, 2003
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calamity Marcy Wu"s famous line in the show when she battles the core/moon
person: sooo.. calamity Marcy Wu..?

me: NAT 20 BABY!!!! WOOOOOOOOO!
by Nat 20 BABYYYYYYYY <3 January 6, 2023
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